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New drug that reduces HIV infections by 90 percent
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New drug that reduces HIV infections by 90 percent - November 23, 2010, 02:55 PM

Hiest must be on vacation...so ill fill in a little.

A drug that reduces HIV infections by 90 percent

A single pill could reduce your risk of HIV infection dramatically, a new study found. But are you willing to spend $12,000 a year and risk headaches and nausea just to stay HIV-negative?
According to the New York Times, an existing HIV medication called Truvada reduced HIV infection rates dramatically in a study of 2,500 men:
In the study, published Tuesday by the New England Journal of Medicine, researchers found that the hundreds of gay men randomly assigned to take the drugs were 44 percent less likely to get infected than the equal number assigned to take a placebo.
But when only the men whose blood tests showed they had taken their pill faithfully every day were considered, the pill was more than 90 percent effective, said Dr. Anthony S. Fauci, head of the division of the National Institutes of Health, which paid for the study along with the Bill and Melinda Gates Foundation.
"That's huge," Dr. Fauci said. "That says it all for me."
The bad news is that Truvada costs $12,000 to $14,000 in the U.S., although a generic version is available in the third world that costs just 40 cents a pill. And although Medicare and insurance companies will pay for HIV drugs for people who are already infected, there are no policies on covering the drugs for uninfected people. And the pill does have "minor" side effects, notably nausea and headaches. Also, some researchers are worried that widespread use of Truvada for preventive purposes could lead to drug-resistant strains of HIV — if someone gets infected and keeps taking just Truvada, the virus could develop a resistance to it, and they could pass on that resistant strain to others.
But still, this is a major step forward in the battle against HIV — now we just need to figure out the most cost-effective and safest way to get it to high-risk populations in the third world. [New York Times via The Atlantic]


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November 23, 2010, 02:58 PM

Sex trip to Africa (super adventure club style), who's in??? Woot! woot!


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November 23, 2010, 03:12 PM

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Originally Posted by Naked_Biker View Post
Sex trip to Africa (super adventure club style), who's in??? Woot! woot!
didn't know you were into barebacking


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November 23, 2010, 03:16 PM

WOW!
but then again this is also a fail because of the price!!

Maybe this is the drug that has kept Magic well as he can afford $12K-14K to spend on this!

as for the generic version @ 40 cents a pill which will probably have you shittin and vomiting!!! PASS!

Last edited by Mr Infinit; November 23, 2010 at 03:19 PM..
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November 23, 2010, 03:19 PM

Quote:
Originally Posted by Mr Infinit View Post
WOW!
but then again this is also a fail because of the price!!

Maybe this is the drug that has kept Magic well as he can afford $12K-14K to spend on this!
Magic is already infected. This drug would do him no good.


Then again... That's just me.

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November 23, 2010, 03:24 PM

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Originally Posted by Slow View Post
didn't know you were into barebacking
he's from Africa....dats whut dey do !


plus IN !!!


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November 23, 2010, 03:27 PM

did anyone watch the first resident evil?

yup...when reports surface that HIV was a manfactured virus then I'll start being excited.

I mean come on...God gave us an immune system then He gave man the power to engineer a virus that could strip that very immune system away...???

Quite different to cancer in which EVERYONE already has it present in your body it just takes time and certain lifestyle habits to activate the cancerous cells to multiply or quite differnt to other terminal illness and dieease

...of course they had pills to "reduce" your chance of getting it. I mean hell they made the virsus itself. How convenient is it that this virsus is passed thought bodily fluid transmission....jeez pull the wool out of your eyes guys.


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November 23, 2010, 04:03 PM

"Good news: you've completed the study Antoine! Here's the $550 we owe you. Bad news: you were in the placebo group and are now HIV positive"


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November 23, 2010, 04:57 PM

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"Good news: you've completed the study Antoine! Here's the $550 we owe you. Bad news: you were in the placebo group and are now HIV positive"
I'm surprised the authors of the study got approval from their respective Institutional Review Boards.


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November 23, 2010, 05:18 PM

How exactly do they set up control groups for these sorts of studies?

These sorts of studies are not set up the same way regular placebo studies are set up.
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November 23, 2010, 05:58 PM

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How exactly do they set up control groups for these sorts of studies?

These sorts of studies are not set up the same way regular placebo studies are set up.
Shazam (see attached). Obviously the subjects they enrolled in the study were at the time of enrollment through to the end of the study at risk for contracting HIV. That means they were having sexual contact with potentially HIV-infected partners. I haven't read the whole article yet so I'll hold further comment until I get it read.
Attached Files
File Type: pdf GrantRMetal2010.pdf (550.6 KB, 1 views)


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November 23, 2010, 07:02 PM

There was a similar trial done in Thailand recently. Phase III is a big deal.

Thai Phase III HIV Vaccine Clinical Trial – RV144 | MHRP

Quote:
Phase III HIV Vaccine Trial

The Thai Phase III HIV vaccine clinical trial, also known as RV144, tested the “prime-boost” combination of two vaccines: ALVAC® HIV vaccine (the prime) and AIDSVAX® B/E vaccine (the boost). The vaccine combination was based on HIV strains that commonly circulate in Thailand.

The study was made possible by an international collaboration involving numerous partners from the Thai and U.S. governments, private companies, non-profit organizations and more than 16,000 volunteers.
Results

The trial demonstrated that the vaccine regimen was safe and modestly effective in preventing HIV infection. The results show that the prime-boost combination lowered the rate of HIV infection by 31.2 percent compared to placebo based on the modified intent-to-treat (mITT) population (n=51 vs. n=74, respectively; p=0.04).

Detailed results were presented on October 20, 2009 by the trial collaborators to researchers gathered at the AIDS Vaccine 2009 Conference in Paris, France and published online by the New England Journal of Medicine. While the efficacy is modest, this study represents a significant scientific achievement.

The trial results, first announced by trial collaborators on September 24, 2009, are based on the mITT population, which is the most clinically relevant analysis for this proof-of-concept study. Data from the mITT population, which was monitored by the independent Data and Safety Monitoring Board during its periodic review of the study, include all volunteers who entered the study less seven individuals who were already HIV-infected on the first day of vaccination.

The vaccine regimen had no effect on the amount of virus in the blood of volunteers who became HIV-infected during the study.

This finding has important implications for the design of future HIV vaccines and how they are tested; however, additional research is needed to better understand how this vaccine regimen reduced the risk of HIV infection.
Next Steps

We now have evidence that a safe and effective HIV vaccine is possible, and the results should accelerate research efforts towards a more effective vaccine. The study partners are already consulting with scientific and product development experts to determine the need for additional research of the RV144 vaccine regimen to better understand how it protected against HIV infection.

In addition, we have already learned a great deal from this study, particularly in terms of conducting large-scale HIV prevention trials, and will continue to learn more as additional research is conducted.

Given the significant threat of HIV infection worldwide, an efficacious vaccine is urgently needed as part of a broader prevention effort to help control the epidemic. It is important to note that a vaccine must be seen as part of a comprehensive approach to prevention of HIV infection.
Study Background

With the emergence of an explosive HIV epidemic in Thailand in the early 1990s, Army researchers helped to characterize the heterosexual epidemic, isolated Thai viruses, and made these sequences available to companies developing HIV vaccines. Army researchers have had a long-standing relationship with the Royal Thai Army, Thai Ministry of Public Health and other Thai vaccine experts, and together they developed a plan to test this candidate vaccine in Thailand.

The Thai government has shown a remarkable and successful dedication to HIV prevention, and it has a longstanding commitment to the development of an HIV vaccine as an additional HIV control measure.
Study Sponsor

The study was sponsored by the U.S. Army and conducted by the Thailand Ministry of Public Health.

The U.S. Military HIV Research Program provided overall project leadership, and the U.S. Army Medical Component – Armed Forces Research Institute of Medical Sciences (AFRIMS) helped execute the trial in Thailand on behalf of the Sponsor.

AFRIMS is a Special Foreign Activity of Walter Reed Army Institute of Research (WRAIR) hosted by the Royal Thai Army and staffed by American and Thai personnel. For almost 50 years, AFRIMS has been America's premier Asian site to study infectious diseases of military importance.

This study was supported by a cooperative agreement with the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Last edited by Rail; November 23, 2010 at 07:52 PM..
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November 23, 2010, 07:23 PM

Round up everyone with HIV, eliminate them. BAM! one world problem fixed.

Next problem North Korea.
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November 23, 2010, 08:26 PM

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Originally Posted by The Bogert View Post
Round up everyone with HIV, eliminate them. BAM! one world problem fixed.

Next problem North Korea.
Round up North Koreans, eliminate them. BAM!. one world problem fixed.

Next problem sharks with lazors


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November 23, 2010, 09:32 PM

man...i know life was great back in the 60's....
all you had to worry about was pissing a lil fire and cracking some eggs....

asked back then...you got a condom...the reply would have been...a condom? wtf is that????

well untill they knock a few items off the list Ill still be Lord Von...the King of Condoms - circa - 1990 - 2010. Celebrating 20 years of protected sex.


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