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They found a cure for Cancer?
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They found a cure for Cancer? - May 16, 2007, 11:34 AM

Scientists cure cancer, but no one takes notice
By: David McRaney
Posted: 1/23/07
EDITORS NOTE:

Since the original publication of this article we have been inundated with responses from the public at all walks of life. It is important to note that research is ongoing with DCA, and not everyone is convinced it will turn out to be a miracle drug. There have been many therapies that were promising in vitro and in animal models that did not work for one reason or another in humans. To provide false hope is not our intention. There is a lot of information on DCA available on the web, and this column is but one opinion on the topic. We hope you will do your own research into the situation. So, we have added links to resources at the end of this column. If you are arriving here form a linking website like Fark, then those links will not appear because they tend to grab only the text. For those visitors, here is a link to the original research: www.depmed.ualberta.ca/dca

END NOTE

Scientists may have cured cancer last week.

Yep.

So, why haven't the media picked up on it?

Here's the deal. Researchers at the University of Alberta in Edmonton, Canada found a cheap and easy to produce drug that kills almost all cancers. The drug is dichloroacetate, and since it is already used to treat metabolic disorders, we know it should be no problem to use it for other purposes.

Doesn't this sound like the kind of news you see on the front page of every paper?

The drug also has no patent, which means it could be produced for bargain basement prices in comparison to what drug companies research and develop.

Scientists tested DCA on human cells cultured outside the body where it killed lung, breast and brain cancer cells, but left healthy cells alone. Rats plump with tumors shrank when they were fed water supplemented with DCA.

Again, this seems like it should be at the top of the nightly news, right?

Cancer cells don't use the little power stations found in most human cells - the mitochondria. Instead, they use glycolysis, which is less effective and more wasteful.

Doctors have long believed the reason for this is because the mitochondria were damaged somehow. But, it turns out the mitochondria were just dormant, and DCA starts them back up again.

The side effect of this is it also reactivates a process called apoptosis. You see, mitochondria contain an all-too-important self-destruct button that can't be pressed in cancer cells. Without it, tumors grow larger as cells refuse to be extinguished. Fully functioning mitochondria, thanks to DCA, can once again die.

With glycolysis turned off, the body produces less lactic acid, so the bad tissue around cancer cells doesn't break down and seed new tumors.

Here's the big catch. Pharmaceutical companies probably won't invest in research into DCA because they won't profit from it. It's easy to make, unpatented and could be added to drinking water. Imagine, Gatorade with cancer control.

So, the groundwork will have to be done at universities and independently funded laboratories. But, how are they supposed to drum up support if the media aren't even talking about it?


Someone check snopes and see if this is true...Toll Brothers Corp. Office just added that site to the "Blocked" list.
If this has any kind of truth to it...I hope they act on it and quick


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May 16, 2007, 11:45 AM

Interesting read....would be nice to find a cure for cancer...amongst other things.


Wow. Just..................wow.
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May 16, 2007, 11:52 AM

http://www.thecancerblog.com/2007/01...shrink-tumors/
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May 16, 2007, 11:57 AM

Wiki

Potential cancer applications

Cancer cells generally use glycolysis rather than oxidation for energy (the Warburg effect), as a result of hypoxia in tumors and damaged mitochondria.[8] The body often kills damaged cells by apoptosis, a mechanism of self-destruction that involves mitochondria, but this mechanism fails in cancer cells.

A study published in January 2007 by researchers at the University of Alberta,[9] testing DCA on in vitro cancer cell lines and a rat model, found that DCA restored mitochondrial function, thus restoring apoptosis, killing cancer cells in vitro, and shrinking the tumors in the rats.[10]

The historical likelihood that a promising agent in pre-clinical (i.e., cell-line killing) experiments will become an effective human cancer drug is 5%, and the likelihood of an FDA approval for any given drug entering Phase I testing is reportedly 8-11%. As of April 2007, DCA has passed phase 1 trials and can enter directly phase 2 trials in patients with cancer


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May 16, 2007, 11:59 AM

Quote:
Sadly, this drug -- that appears to work remarkably well -- may never benefit cancer patients. All because no one stands to make billions of dollars from it.


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May 16, 2007, 12:02 PM

I find this irony humorous... pharmecutical companies and thier ads promising compassion, and caring...

The overwhelming hope is that DCA will move right to human testing. But the overwhelming fear is that it will not -- because of economic reasons. There is no longer a patent on DCA so it is not owned by any one company. With little chance of one group making a large profit, there may be no incentive for pharmaceutical companies to invest in research.

Sadly, this drug -- that appears to work remarkably well -- may never benefit cancer patients. All because no one stands to make billions of dollars from it.


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May 16, 2007, 12:12 PM

so are the internet whores saying this is legit?


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Thumbs up May 16, 2007, 12:15 PM

http://www.depmed.ualberta.ca/dca/
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May 16, 2007, 12:17 PM

I rember reading about this drug not that long ago. Around January.

http://www.newscientist.com/channel/...t-cancers.html

Interesting article, the drug is DCA, and has been in use for many years for other reasons.

"The next step is to run clinical trials of DCA in people with cancer. These may have to be funded by charities, universities and governments: pharmaceutical companies are unlikely to pay because they can't make money on unpatented medicines. The pay-off is that if DCA does work, it will be easy to manufacture and dirt cheap."

Link to the college doing primary research.
http://www.depmed.ualberta.ca/dca/

It is necessary for the Government and for CHARITIES to fund these studies.

As some of you know I am always watching things such as this, and this is why I want so badly for people to support charties, ones like the Leukimia Lymphoma society, which my girlfriend is currently raising funds for:

Man/Woman of the year


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May 16, 2007, 12:24 PM

Wait a minute, how will they not make millions?

think about it.
1. a certain % of people get cancer that then must be treated
2. of those, a large fraction are "cured", at high cost (chemo, etc) though, since the % of cancer is relatively low, its easy for insurance to cover this.
3. some fraction re-occur, BUT that is a small fraction of the small fraction, which are again treated at high cost (same caveat about insurance)
4. this drug TREATS cancer, its not a preventative
5. if it was all about profits, we'd have a crapload of drugs enabling people to live with cancer...considering the vast majority of cancer treatments are designed to eliminate it, that doesn't hold water...the reason being, cancer is lethal enough where extending the treatment to make money will have negative consequences for the patient

so basically, if it worked, sell it for the same price as current drugs, which is not a burden (in the vast majority of cases), will provide higher remission rate / cure rate. The companies aren't making money off the recurrence treatments.

I think this article is misguided in its reasoning why it hasn't been invested in, which could be any of the following:
1. the university doesn't have in place agreements with various companies, and could be demanding too high of a fee for the drugs
2. its in canada, land of sociallized medicine...not much money there, I don't know if those laws affect meds developed there
3. the company believes there are options with more efficacy, that itself is developing

remember, its a freakin capitalist economy...and pharmacutical companies are a part of it. and its that drive for better products that the vast majority of the time gives us better drugs.


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May 16, 2007, 12:28 PM

If true, it's sadly one great uncle too late.
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May 16, 2007, 12:41 PM

Quote:
Originally Posted by boston-birdman

so basically, if it worked, sell it for the same price as current drugs,
There is no patent left on the drug, so any pharmaceutical company can make it. A high price would not work because any number of facilities can produce it and will under cut the price of their competitors.

Once a drug is outside its patent time generic equivalents come on the market at costs just over the cost of production.

There is very very little room for profit in supplying this drug. As such no big company is going to fund the study of this drug in cancer patients.






Again, this is where government funding and charities need to supply the funding for testing.


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May 16, 2007, 12:56 PM

Can't a private company just change the formula?

Most drug patents serve to give the inventing company a head start, not to allow them to dominate the field. Aspirin has no patent, yet plenty of companies continue to research it to find better applications (It can prevent heart disease!). Whatever company funds the research for this can patent a specific formula that includes DCA and make huge profits. Other companies can produce the drug, but every new formulation (that requires trials and testing) gets a patent, right?


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May 16, 2007, 01:00 PM

Quote:
Originally Posted by Madali
If true, it's sadly one great uncle too late.
+1 Mom too late.


When it hits close to home...it makes it worse to know that Its there...but they dont use it.


"Well behaved women seldom make history"~~Laurel Thatcher Ulrich
"Damn white girls throwin' gang signs!"
Gangsta= High-siding on a 50cc!!
Also, if you take your jacket off and the women are all smiles, then you take your helmet off and 99% of the women look disappointed, please put your helmet back on. kthxbai.-Bexxx
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May 16, 2007, 01:01 PM

That may not be true anymore kat, a recent supreme court ruling may make that practice (which is stifling to innovation) obsolete in that the new requirement of "unique and non-obvious" includes the (to those in that trade), the "obvious" combination of two already patented or unpatented items...its the components that carry the IP rights (if their assembly is obvious)


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